PT-141 Bremelanotide for Sexual Enhancement in Men and Women

PT-141 Bremelanotide, as an injection, is FDA-approved to treat hypoactive sexual desire disorder in women, but the peptide’s affect was originally discovered in men. While researching a drug to darken skin, researchers noticed that men got spontaneous erections.

Studies on intranasal administration of PT-141 reported the spray may have the same impact as the injection.

An article published in The Journal Nature on the effect of PT-141 nasal spray in with ED and men without ED, showed the effects of PT-141 nasal were “clinically significant”. Both study groups achieved erections when using the PT-141. Depending on physician’s recommendation, bottle may contain up to 8 doses.

What Is PT-141?

PT-141 is an agonist at melanocortin receptors. This means it activates the receptors, causing a response. Melanocortin receptors control sexual function, impact appetite, and immunity, among other physiologic actions.

PT-141 offers promise treating sexual dysfunction in men and women who do not have success with the PDE5 inhibitors Viagra (sildenafil) and Cialis (tadalafil) or can’t take sildenafil or tadalafil for health reasons.  Dr. Birken does prescribe both the injectable form as well as the nasal form that has both PT-141 and low dose sildenafil for men and women.

How PT-141 Works

PT-141 is a peptide drug that affects neurotransmitters in the brain called melanocortins. It is not known exactly how PT-141 can cause erections in men and increase women’s libido and sexual satisfaction.

What Is the Difference Between PT-141 And Cialis And Viagra?

PT-141’s main works in the brain, while Cialis (tadalafil) and Viagra (sildenafil) essentially impact blood vessels.

 

For more information, contact the office at 281-419-3231 and press option 2 or email at info@drbirken.com

Melatonin Health Benefits

Uses

Melatonin is a natural hormone that appears to have only minor side effects. For this reason, researchers have tested it for use as a natural supplement in several medical conditions, including:.

 

Sleep disorders

Natural melatonin lets the body know that it is time to sleep. Melatonin supplements have had varying success in treating sleep problems.

 

A 2013 meta-analysis of studies suggested that melatonin helps improve sleep duration, reduce the time it takes to fall asleep, and improve the quality of sleep compared to a placebo.

 

While melatonin does not work as effectively as some sleep aids, it has fewer side effects than other drugs.

 

In another review of studies from 2014, melatonin showed promise for preventing shifts in sleep and wake times in people with jet lag and improving sleep in people with insomnia. The benefits of the supplement in shift workers and healthy adults were less clear.

 

Headaches

There is evidence that melatonin can relieve some headaches.

 

In particular, it may be useful for migraine and cluster headaches. However, researchers do not know which formula and dose might work best for people with headaches.

 

Cancer

Some clinical studies of colon, breast, renal, brain, and lung cancer suggest that melatonin might support cancer treatment when a person takes it alongside chemotherapy and radiation therapy.

 

However, the evidence is far from definitive, and scientists need to carry out more research to confirm the link.

 

The available evidence suggests that melatonin may help combat cancer when it starts, multiplies, and progresses. There are many ways in which this supplement may work on cancer.

 

Anyone wanting to take melatonin should discuss it with their cancer doctor, or oncologist, to make sure it will not interfere with their cancer treatments

 

Researchers are trying to pinpoint its specific actions but suggest it holds a lot of promise.

 

Alzheimer’s disease

Melatonin levels decrease with age. However, this reduction is more pronounced in people with Alzheimer’s disease. A 2013 study found that melatonin appears to slow the cognitive decline associated with Alzheimer’s.

 

Tinnitus

The findings of a 2014 study suggested that melatonin might slightly improve the symptoms of tinnitus. This effect may be due to improved sleep or the antioxidant properties of melatonin.

 

Protection from Radioactivity

Radiation therapy plays a key role in treating many types of cancer. However, it is toxic and can cause severe side effects. Much of the damage radiation causes is due to harmful substances called free radicals.

 

Melatonin is an antioxidant that helps combat the damaging effects of free radicals, plus it has anticancer effects. Some research suggests that it might provide benefits for people who receive radiation therapy during cancer treatment.

 

Other Health Benefits:
Taking melatonin may help with a few different health conditions, including:

 

Jet lag

Delayed sleep-wake phase disorder (DSWPD)

Sleep problems in children with attention-deficit hyperactivity disorder (ADHD) and autism

Anxiety before and after surgery

One report suggests that melatonin may also provide the following benefits by:

 

Protecting the heart by reducing blood pressure in people with insomnia

Having protective effects against cancer and enhancing the impact of cancer treatments

Reducing stroke damage

Reducing the damaging effects of obesity on the body by lowering inflammation

Slowing mental decline in people with dementia

However, more research will be necessary to prove these benefits in clinical trials.

 

Conclusions

Melatonin has many functions within the human body, most of which we are yet to understand. Based on current research, it is most helpful for sleep issues, such as jet lag, as well as for anxiety.

It also seems that melatonin might be useful in the treatment of some illnesses.

Dr. Birken’s office carries a pharmaceutical grade melatonin and suggest starting at 3 mg before bed and increasing till one reaches an effective dose for sleep.

Dr. Birken takes 9 mg before bed.  Some patients only need 3 and some require even higher doses.

Contact Erica@drbirken.com

7 Benefits of Mindfulness Meditation

From Calm

  1. Reduced Stress

Mindfulness meditation has been scientifically shown to get at the root of the problem of stress: our brain’s over-active tendency to see potential disaster everywhere we look.

When we sit mindfully, we become aware of the constant sense of urgency and discontent in our mind.

What’s revolutionary about meditation is that instead of feeding this stress by doing more or speeding up, we do the opposite. We slow down, and focus on something simple and unproblematic like our breath. After we’ve started to calm down a little, we can observe those stressful feelings and thoughts without getting swept up in them.

Over weeks and months of regular practice, our brains actually change. We react less strongly to difficult situations and when we do get triggered, we recover faster.  We still live in a stressful world, but with meditation we learn to face it all a lot better.

 

 

  1. Better Focus

As an easily distracted kid, my teachers often shouted, “Pay attention!” But nobody ever taught me how to do this. Imagine if teachers taught 5th grade math by repeatedly shouting, “Add fractions!”

The good news is, concentration can be learned just like any other skill.  All it takes is practice and good instruction. In meditation, we cultivate concentration by repeatedly bringing our attention back to a chosen point of focus, often our breath or some other sensation in the body. What we choose to focus on is less important than the fact that we pick something and stick with it. Over time, our attention begins to go where we tell it rather than being drawn every which way by random impulses.

 

  1. Improved Flow

Meditation lets us slip into the groove of a task with more ease. The key to entering into flow is to be relaxed but alert, focused but not uptight.  Non-meditative concentration tends to use a lot of brow-furrowing effort, which creates tension and discomfort, and actually prevents us from getting into a state of flow.

In meditation, rather than tightening up around our point of focus, we relax into it. This allows the mind to settle down, and let us really sink into what we’re doing. The same principle applies when we’re writing computer code or playing the saxophone. We enter flow when we’re vibrantly engaged with what we’re doing while at the same time we relaxing into it.

 

  1. Increased Happiness

More and more research is showing that real happiness doesn’t come from possessions or success. It comes from the quality of our experiences.  Meditation leads to more happiness by improving our ability to notice and appreciate pleasurable experiences, while cushioning some of life’s hard edges.

Technology has brought us all kinds of comforts and luxuries. Yet even with all this progress and innovation, we still face face pain, illness, and everyday annoyances. These can sabotage our ability to enjoy life. Mindfulness teaches us how to be more fully aware and accepting of painful experiences as they happen. Studies of the brain have shown that this has a counter-intuitive effect: increased awareness of pain results in less activation in brain areas associated with suffering.

With pleasurable experiences, the effect of mindfulness is the opposite. By allowing us to be vividly present to the joy and goodness of these experiences, we magnify the positive impact they have on our happiness.

 

 

  1. Stronger resilience in the face of life’s challenges

Life’s big challenges inevitably visit us as unwanted guests, whether a loss, a layoff, or a trauma. When we get hit hard, meditation can help us recover faster and grow from adversity.

When something awful has just happened, the most counter-intuitive thing in the world is to focus on something that has nothing to do with what we’re facing. Mindfulness gets us in the habit of doing just that, noticing things like the sunlight reflecting off the leaves outside our window, or the quiet purr of the ceiling fan.

We notice that the present moment is filled with a bunch of very ordinary things that aren’t contaminated by fear, pain, anger, or loss. Focusing on something emotionally neutral in a time of distress is like a secret ninja move that lets us slip sideways past our gnawing awareness of the terrible event.

That doesn’t make the bad stuff go away. But it does give us a break from our suffering. It gives us a starting point in the here and now to collect ourselves so we can courageously face the future.

 

 

  1. Better Relationships

The hidden emotional forces within a single person are complicated enough but put two people together and you’ve got a real tangle.

In our important relationships, the stakes are often very high, and we can see our ugliest side come out. We want so badly for things to work out that we become flooded with emotion when things go wrong. The problem isn’t the fact that we’re emotional creatures. Emotions are what allow us to form and strengthen relationships in the first place. The problem is that these emotional forces can get out of control, driving us to say or do things we regret.

Meditation teaches us the be more aware of our own feelings and the feelings of those we care about.6 Emotional awareness is just the first step. We also learn how to step back, take a breath, and choose our response with clarity and compassion. Our usual feelings still arise —fear of abandonment, rage at a perceived slight, and many others. But instead of shutting down or screaming or running away, we learn to notice and name these feelings while maintaining a calm stable center.

 

  1. Health

Scientists are starting to uncover many ways that meditation can improve our physical health, addressing problems like high blood pressure, diabetes, and chronic pain.

For decades, doctors have known that stress is one of the biggest contributors to problems with our health. When we’re under chronic stress, it’s not just a mind thing. Stress affects the whole body, leading to inflammation, pain, trouble with digestion, and lowered immunity. So it shouldn’t come as a surprise that meditation, which lowers our overall stress level, also improves our basic physical functioning.

 

New Approaches to Weight Loss

From The New York Times

Kicking dieting habits this time of year is especially hard because of the allure of gimmicky weight-loss plans. Many established diet programs and dieting apps try to attract users with the promise that they’re not promoting a traditional diet, only to impose restrictive eating practices once you sign up.

Traci Mann, who heads the health and eating laboratory at the University of Minnesota, notes that beyond the disappointment of not keeping weight off, dieting also affects your body in a number of negative ways. Among other things, restrictive eating can affect memory and executive function, lead to obsessive food thoughts and trigger a surge in cortisol, a stress hormone.

“A diet is an unpleasant and short-lived way to try to lose weight,” said Dr. Mann, author of “Secrets From the Eating Lab: The Science of Weight Loss, the Myth of Willpower, and Why You Should Never Diet Again.”

“You might take it off in the short term, but it comes back,” Dr. Mann continued. “It happens no matter who you are; it happens to people with great willpower and to people with crappy willpower.”

If you’re still tempted to try that fad diet, consider this: Evidence suggests that restrictive dieting and rapid weight loss can lead to lasting changes that may slow your metabolism, alter hormones that regulate hunger and hamper efforts to maintain your weight. A weight-reduced body responds differently to food and exercise than a body that has not dieted, studies suggest, and a dieter’s muscles may burn fewer calories than expected during exercise. These changes help explain why many chronic dieters may be eating far fewer calories than those around them, but still aren’t losing weight, said Dr. Rudolph Leibel, a professor of medicine at Columbia University’s Institute of Human Nutrition.

 

How eating habits are formed

Dr. Brewer, an addiction psychiatrist, has tested a number of mindfulness practices to help people quit smoking, lower anxiety and reduce emotional eating. He has also created an app called Eat Right Now that uses mindfulness exercises to help people change their eating habits.

One Brown University study of 104 overweight women found that mindfulness training reduced craving-related eating by 40 percent. Another review by scientists at Columbia University found that intuitive and mindful eating training often resulted in at least one benefit for metabolic or heart health, such as improved glucose levels, lower cholesterol or improved blood pressure

Dr. Brewer notes that eating behaviors, like absentmindedly snacking on potato chips or bingeing on dessert, are often the result of habit loops that get reinforced over time.

Habit loops can be formed from both good and bad experiences, explains Dr. Brewer. Ice cream, for instance, is something we might eat during celebrations. The brain learns to associate eating ice cream with feeling good. While there’s nothing wrong with ice cream, it can become a problem when we start eating it unthinkingly after an emotional trigger, such as when we feel stressed or angry. Now our brains have learned that ice cream also makes us feel good in times of stress, reinforcing the habit loop.

Over time, we can develop a number of habit loops that trigger us to eat when we’re bored, angry, stressed, tired after work or even just watching television. “What’s tricky about habit loops,” Dr. Brewer said, “is that the more automatic they become, over time you’re not even consciously choosing these actions.”

By understanding your own habit loops and the triggers behind them, Dr. Brewer explained, you can help break the hold they have on you by updating your brain with new information. Mindfulness exercises, which prompt you to slow down and think about how and why you’re eating, can teach your brain that a “feel good” food doesn’t actually make you feel as good as you remembered. Practicing mindfulness each time you reach for a food or decide to eat it can interrupt the habit loop.

 

Try the Eat Well Challenge

For this week’s Eat Well Challenge, start practicing awareness by slowing down and thinking about what you’re eating and why you’re eating it. Try not to focus on weight loss, food restriction or eliminating favorite foods from your diet. Avoid labeling foods as “good” or “bad.” Your goal this week is to focus on the tastes and textures of food, and how you feel before, during and after eating.

It can take time to learn how to bring mindful awareness to what you’re eating, so be patient. In one study, it took participants at least 10 to 15 tries — and for many people it took 38 or more attempts — to begin to reshape eating behaviors.

Here are two simple exercises from Dr. Brewer’s Eat Right Now program to get you started.

Begin with a pre-meal warm-up.

Before every meal this week, try this simple awareness exercise. There’s no need to track what you eat or restrict your diet. Just check in with your body every time you eat. On a scale of zero to 10, with zero being an empty stomach and 10 being uncomfortably full, how hungry are you right now? Next, look at the food, observing the textures and colors. Now smell your food. Finally, pick up your fork and take your first mindful bite. As you chew, put your fork down and pay careful attention to how the food tastes and feels in your mouth. After several bites, check in with your body to see if you’re hungry or full.

Map your eating habits.

Use this exercise to work on an eating behavior you’d like to change, like excessive snacking or ordering fast food. Our eating habits have three elements: a trigger, a behavior and a result. By mapping your habits, you can provide your brain with new information about how the habit really makes you feel.

Start by choosing one eating behavior you’d like to change. Maybe you want to snack less during the day, cut back on takeout or indulgences like cookies, potato chips or ice cream. While there’s nothing wrong with enjoying these foods, you’ve identified this as a problematic eating behavior. Why is that?

Now think about what triggers this behavior. Is it an emotion, like anger or stress, or are you rewarding yourself with a treat? Or it could be a situation, like watching television or grocery shopping when you’re hungry.

Focus on the result. Before you eat, ask yourself some questions. What am I getting from this? How will eating this food make me feel? Think about how you felt the last time you ate it. Did you enjoy it? Did you end up eating too much? Did you feel uncomfortably full or nauseous? Did you feel guilty later and beat yourself up for eating it? Thinking about how a food makes you feel before, during and after you eat updates the information your brain has about how rewarding (or not) a food really is. And it can help break the hold a particular food has on you.